A flat panel display with detachable anti-vibrate speaker includes a speaker body with a front bezel attached at least one speaker driver, a rear bezel and a middle frame. The middle frame with a bottom positioning hole is made of an elastic material and situated between the front bezel and the rear bezel, and an elastic rib is formed on an inner surface of the middle frame to separate and to be against the front bezel and the rear bezel. A stand includes a positioning structure and a top surface groove. The positioning structure is assembled inside the top surface groove and is blocked by a blocking member fixed on an upper surface of the top surface groove. An elastic member is situated in the bottom of the top surface groove and a positioning member with a round top is located between the blocking member and the elastic member and is pushed to fit the positioning hole by the elastic member.