发明申请
US20070265246A1 Treatment of an Intestinal Adenoma and/or Adenocarcinoma by Inhibition of Notch Pathway Activation
审中-公开
通过抑制Notch途径激活治疗肠腺瘤和/或腺癌
- 专利标题： Treatment of an Intestinal Adenoma and/or Adenocarcinoma by Inhibition of Notch Pathway Activation
- 专利标题（中）： 通过抑制Notch途径激活治疗肠腺瘤和/或腺癌
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申请号： US11667419申请日： 2005-11-10
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公开(公告)号： US20070265246A1公开(公告)日： 2007-11-15
- 发明人: Johannes Clevers , Maria Van Gijn , Johannes Van Es
- 申请人： Johannes Clevers , Maria Van Gijn , Johannes Van Es
- 优先权： EP04078090.0 20041110; EP05075806.9 20050406
- 国际申请： PCT/NL05/00788 WO 20051110
- 主分类号： A61K31/55
- IPC分类号： A61K31/55 ; C12N5/06
摘要：
The invention relates to the field of biochemistry and medicine. More specifically the invention relates to methods and pharmaceuticals for the treatment of intestinal neoplasia. The invention discloses the surprising finding that inhibitors of Notch pathway activation (for example γ-secretase inhibitors) are extremely useful in the treatment of intestinal adenoma and/or adenocarcinoma.
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