发明申请
US20070275061A1 PHARMACEUTICAL COMPOSITIONS AND FORMULATIONS OF METFORMIN EXTENDED RELEASE TABLETS
审中-公开
金属蛋白酶扩展片剂的药物组合物和配方
- 专利标题: PHARMACEUTICAL COMPOSITIONS AND FORMULATIONS OF METFORMIN EXTENDED RELEASE TABLETS
- 专利标题(中): 金属蛋白酶扩展片剂的药物组合物和配方
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申请号: US11534359申请日: 2006-09-22
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公开(公告)号: US20070275061A1公开(公告)日: 2007-11-29
- 发明人: Young Gwan Jo , Ja-Seong Koo , Ju-Bin Yim , Yoon-Sik Jun
- 申请人: Young Gwan Jo , Ja-Seong Koo , Ju-Bin Yim , Yoon-Sik Jun
- 优先权: KR10-2006-0046145 20060523
- 主分类号: A61K9/22
- IPC分类号: A61K9/22 ; A61K31/155
摘要:
The present invention relates to a metformin extended release tablet, particularly to a metformin extended release tablet comprising metformin, which is effective in treating non-insulin dependent diabetes mellitus, as active ingredient, and a matrix in which hydrophilic polymers and hydrophobic materials are mixed at a specific proportion. The hydrophilic polymers enable controlling of the pore size of the gel layer formed by water swelling, thereby enabling primary control of drug release rate. And, the hydrophobic materials block the pores of the gel layer, thereby enabling secondary control of drug release rate. Therefore, the metformin extended release tablet of the present invention has better dissolution properties than conventional extended release tablets and, thus, enables extended drug release at constant rate even with less matrix. A constant blood level can be maintained with one administration a day and the tablet can be made smaller, which makes the administration easier and the production simpler.
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