A system and method for imaging one or more objects in the presence of unknown phase and amplitude aberrations is described. Multiple images are collected so as to have measurement diversity and processed using a model-based approach to estimate the aberrations. An incoherent imaging model may be constructed to estimate the dependence of the imagery upon the object and the optical system, including the aberrations. A probability density function may then be calculated using the estimated model. Next, a maximum-likelihood estimate may be calculated and optimized, thus yielding a close approximation of the phase and amplitude aberrations. The estimates may then be used to estimate an image of the object or correct the system for future imaging.