A method is provided for evaluating pellet-cladding interaction (PCI) in a nuclear core having a reactor protection system and a plurality of elongated fuel rods each having fuel surrounded by cladding with a gap therebetween. The method includes: selecting a number of core parameters to be analyzed; evaluating the selected parameters at a plurality of statepoints; generating a model of an operating space of the core based, at least in part, upon the statepoints; selecting a subset or loci of statepoints from the model wherein each of the statepoints of the loci of statepoints, when subjected to a predetermined transient, falls within the operational limits of the reactor protection system; and evaluating the loci of statepoints for PCI in response to the transient. In this manner, the potential for PCI can be accurately determined without requiring every statepoint for every fuel rod in the core to be individually analyzed.