发明申请
- 专利标题： ANTIBODY VARIANTS
- 专利标题（中）： 抗体变体
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申请号： US11552445申请日： 2006-10-24
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公开(公告)号： US20070280931A1公开(公告)日： 2007-12-06
- 发明人: Yvonne Chen , Henry Lowman , Yves Muller
- 申请人： Yvonne Chen , Henry Lowman , Yves Muller
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; C07K16/18 ; C12N15/13 ; C12N15/81 ; C12N15/85 ; C12N5/10 ; C12P21/00
摘要：
Antibody variants of parent antibodies are disclosed which have one or more amino acids inserted in a hypervariable region of the parent antibody and a binding affinity for a target antigen which is at least about two fold stronger than the binding affinity of the parent antibody for the antigen.
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