发明申请
- 专利标题: Macrocyclic oximyl hepatitis C protease inhibitors
- 专利标题(中): 大环肟基丙型肝炎蛋白酶抑制剂
-
申请号: US11502740申请日: 2006-08-11
-
公开(公告)号: US20070281884A1公开(公告)日: 2007-12-06
- 发明人: Ying Sun , Deqiang Niu , Guoyou Xu , Yat Sun Or , Zhe Wang
- 申请人: Ying Sun , Deqiang Niu , Guoyou Xu , Yat Sun Or , Zhe Wang
- 主分类号: A61K38/12
- IPC分类号: A61K38/12 ; A61K31/395 ; C07K5/12
摘要:
The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.