发明申请
US20070281911A1 Use of Adefovir or Tenofovir for Inhibiting Mmtv-Like Viruses Involved in Breast Cancer and Primary Biliary Cirrhosis
审中-公开
阿德福韦或替诺福韦用于抑制与乳腺癌和原发性胆汁性肝硬化有关的类似Mmtv的病毒
- 专利标题： Use of Adefovir or Tenofovir for Inhibiting Mmtv-Like Viruses Involved in Breast Cancer and Primary Biliary Cirrhosis
- 专利标题（中）： 阿德福韦或替诺福韦用于抑制与乳腺癌和原发性胆汁性肝硬化有关的类似Mmtv的病毒
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申请号： US10586627申请日： 2005-01-21
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公开(公告)号： US20070281911A1公开(公告)日： 2007-12-06
- 发明人: Tomas Cihlar , Janet Douglas , Craig Gibbs
- 申请人： Tomas Cihlar , Janet Douglas , Craig Gibbs
- 申请人地址： US CA FORSTER CITY, CALIFORNIA 94404
- 专利权人： GILEAD SCIENCES INC.
- 当前专利权人： GILEAD SCIENCES INC.
- 当前专利权人地址： US CA FORSTER CITY, CALIFORNIA 94404
- 国际申请： PCT/US05/02043 WO 20050121
- 主分类号： A61K31/66
- IPC分类号： A61K31/66 ; A61P1/16 ; A61P35/00 ; C12N7/06 ; C12N9/99
摘要：
The active metabolites of adefovir and tenofovir (PMEApp and PMPApp) are active against the MMTV RT. They are 25-fold more potent than 3TCppp, suggesting that tenofovir and adefovir may be effective at inhibiting the MMTV-like retroviruses, which may be the etiological agents involved in PBC and breast cancer.
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