发明申请
US20070281970A1 Quinolinone-Carboxamide Compounds as 5-Ht4 Receptor Agonists
有权
喹啉酮 - 甲酰胺化合物作为5-Ht4受体激动剂
- 专利标题: Quinolinone-Carboxamide Compounds as 5-Ht4 Receptor Agonists
- 专利标题(中): 喹啉酮 - 甲酰胺化合物作为5-Ht4受体激动剂
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申请号: US11547790申请日: 2005-04-06
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公开(公告)号: US20070281970A1公开(公告)日: 2007-12-06
- 发明人: Daniel Marquess , Paul Fatheree , S. Derek Turner , Daniel Long , Seok-ki Choi , Adam Goldblum , Daniel Genov
- 申请人: Daniel Marquess , Paul Fatheree , S. Derek Turner , Daniel Long , Seok-ki Choi , Adam Goldblum , Daniel Genov
- 国际申请: PCT/US05/11393 WO 20050406
- 主分类号: A61K31/4709
- IPC分类号: A61K31/4709 ; A61P1/00 ; A61P1/10 ; A61P1/14 ; C07D451/02
摘要:
The invention provides novel quinolinone-carboxamide 5-HT4 receptor agonist compounds of Formula (I). The invention also provides pharmaceutical compositions comprising such compounds, the use such compounds to treat diseases associated with 5-HT4 receptor activity, and processes and intermediates useful for preparing such compounds. Wherein; R1 is hydrogen, halo, hadroxy, C1-4 alkyl, or C1-4 alkoxy; R2 is C3-4 alkyl, or C3-6cycloakyl; R3 is hydrogen or C1-3 alkyl: R4 is —S(O)2 R6 or —C(O)R7; R5 is hydrogen, C1-3alkyl, C2-3 alkyl subtituted with —OH or C1-3 alkoxy, or —CH2-pyrydyl; R6 is C1-3 alkyl; or R5 and R6 taken together from C3-4 alkylenyl; and R7 is hydrogen, C1-3alkyl, or pyrydyl; or pharmaceutically-acceptable salt or solvate or stereoisomer thereof.
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