The optical-fiber-based radio-frequency identification (RFID) system includes one or multiple RFID readers optically coupled to one or more transponders via respective one or more optical fiber RF communication links. The transponders are each adapted to receive electromagnetic RF tag signals from RFID tags within the associated picocell and transmit optical RF tag signals to the corresponding RFID reader over the corresponding optical fiber RF communication link. The RFID reader then converts the optical RF tag signals to electrical RFID tag signals, and extracts the RFID tag information from the RFID tag signals. The transponders can be arranged spaced apart along the length of one or more optical fiber cables made up of pairs of downlink and uplink optical fibers that constitute the optical fiber RF communication links.