发明申请
- 专利标题: ASPARTYL PROTEASE INHIBITORS
- 专利标题(中): ASPARTYL PROTEASE抑制剂
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申请号: US11759336申请日: 2007-06-07
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公开(公告)号: US20070287692A1公开(公告)日: 2007-12-13
- 发明人: Yusheng Wu , Ulrich Iserloh , Jared Cumming , Xiaoxiang Liu , Robert Mazzola , Zhong-Yue Sun , Ying Huang , Andrew Stamford , Brian McKittrick , Zhaoning Zhu
- 申请人: Yusheng Wu , Ulrich Iserloh , Jared Cumming , Xiaoxiang Liu , Robert Mazzola , Zhong-Yue Sun , Ying Huang , Andrew Stamford , Brian McKittrick , Zhaoning Zhu
- 主分类号: A61K31/513
- IPC分类号: A61K31/513 ; A61K31/4166 ; C07D403/02
摘要:
Disclosed are compounds of formula I or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, U, W, X, R1, R2, R6, R7, R30 and R31 are as described above in the specification. Also disclosed is the method of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases. Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds of formula I in combination with a cholinesterase inhibitor or a muscarinic m1 agonist or m2 antagonist.
公开/授权文献
- US08168641B2 Aspartyl protease inhibitors 公开/授权日:2012-05-01