发明申请
- 专利标题： Aryl-4-ethynyl-isoxazole derivatives
- 专利标题（中）： 芳基-4-乙炔基 - 异恶唑衍生物
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申请号： US11805640申请日： 2007-05-24
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公开(公告)号： US20070287739A1公开(公告)日： 2007-12-13
- 发明人: Bernd Buettelmann , Henner Knust , Andrew Thomas
- 申请人： Bernd Buettelmann , Henner Knust , Andrew Thomas
- 优先权： EP06114745.0 20060531
- 主分类号： A61K31/42
- IPC分类号： A61K31/42 ; C07D261/06
摘要：
The present invention is concerned with aryl-4-ethynyl-isoxazole derivatives of formula I wherein R1 to R5 are as described in the specification and pharmaceutically acceptable salt thereof. This class of compounds has high affinity and selectivity for GABA A α5 receptor binding sites, being useful as a cognitive enhancer or for the treatment of cognitive disorders like Alzheimer's disease.
公开/授权文献
- US07544704B2 Aryl-4-ethynyl-isoxazole derivatives 公开/授权日：2009-06-09
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