发明申请
- 专利标题： Fibronectin III Domain As Leptin Receptor Antagonists
- 专利标题（中）： 纤连蛋白III结构域作为瘦蛋白受体拮抗剂
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申请号： US11791264申请日： 2005-11-16
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公开(公告)号： US20070292434A1公开(公告)日： 2007-12-20
- 发明人: Jan Tavernier , Lennart Zabeau
- 申请人： Jan Tavernier , Lennart Zabeau
- 优先权： EP04105864.5 20041118
- 国际申请： PCT/EP05/56022 WO 20051116
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; A61P3/04 ; C07K16/26
摘要：
The invention relates to a new type of leptin receptor antagonist, which is able to prevent leptin signaling without preventing the binding of leptin to the leptin binding domain. More specifically, the invention relates to the use of a part of the leptin receptor to prevent the leptin-dependent activation of the receptor, and by this the leptin-induced signaling.
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