发明申请
- 专利标题： Polynucleotides encoding novel PCSK9 variants
- 专利标题（中）： 编码新型PCSK9变体的多核苷酸
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申请号： US11824461申请日： 2007-06-28
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公开(公告)号： US20080008697A1公开(公告)日： 2008-01-10
- 发明人: Gabriel Mintier , Jian Chen , John Feder , Bowman Miao , Rex Parker
- 申请人： Gabriel Mintier , Jian Chen , John Feder , Bowman Miao , Rex Parker
- 专利权人： Bristol-Myers Squibb Company
- 当前专利权人： Bristol-Myers Squibb Company
- 主分类号： C12N15/12
- IPC分类号： C12N15/12 ; A61K38/17 ; A61K38/48 ; C12N15/63 ; C12P21/02 ; G01N33/68 ; C12Q1/68 ; C12N9/50 ; C07K14/435 ; C12N1/00
摘要：
The present invention provides novel polynucleotides encoding PCSK9b and PCSK9c polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel PCSK9b and PCSK9c polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
公开/授权文献
- US07572618B2 Polynucleotides encoding novel PCSK9 variants 公开/授权日：2009-08-11
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