Methods, computer program products, electronic devices and information blocks are provided that improve both efficiency of transmission and efficiency of segmentation by enabling an intelligent transport block size determination and a flexible segmentation scheme suitable for utilization with retransmission. One exemplary method involves steps of: determining a size of a transport block based on criteria including a size of at least one data block to be transmitted, wherein the transport block size is determined such that the transport block will include at least one segment of a data block of the at least one data block; segmenting the data block of the at least one data block into a plurality of segments including the at least one segment; and populating the transport block with at least the at least one segment.