发明申请
US20080009542A1 POLYMORPHIC FORM OF FLUORO-7-(2,2,2-TRIFLUOROETHOXY) PHENOXATHIIN-10,10-DIOXIDE
有权
氟代-7-(2,2,2-三氟乙酰)苯氧基-10,10-二氧化物的多晶型
- 专利标题: POLYMORPHIC FORM OF FLUORO-7-(2,2,2-TRIFLUOROETHOXY) PHENOXATHIIN-10,10-DIOXIDE
- 专利标题(中): 氟代-7-(2,2,2-三氟乙酰)苯氧基-10,10-二氧化物的多晶型
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申请号: US11773892申请日: 2007-07-05
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公开(公告)号: US20080009542A1公开(公告)日: 2008-01-10
- 发明人: Elisabeth Brot , Daniel Keefe , Brian Haney , Nigel Metcalfe , Grant Palmer , Paul Isbester
- 申请人: Elisabeth Brot , Daniel Keefe , Brian Haney , Nigel Metcalfe , Grant Palmer , Paul Isbester
- 申请人地址: US NC Cary
- 专利权人: CeNeRx BioPharma, Inc.
- 当前专利权人: CeNeRx BioPharma, Inc.
- 当前专利权人地址: US NC Cary
- 主分类号: A61K31/39
- IPC分类号: A61K31/39 ; A61P25/00 ; C07D497/00
摘要:
Provided herein is a new form of 3-fluoro-7-(2,2,2-trifluoroethoxy)phenoxathin 10,10-dioxide, which demonstrates higher stability relative to other forms of 3-fluoro-7-(2,2,2-trifluoroethoxy)phenoxathiin-10,10-dioxide. In particular, this new form affords less dosage critical administration of 3-fluoro-7-(2,2,2-trifluoroethoxy)phenoxathin 10,10-dioxide relative to other forms. The new solid form of 3-fluoro-7-(2,2,2-trifluoroethoxy)phenoxathiin-10,10-dioxide has been determined and is provided herein. This new solid form of 3-fluoro-7-(2,2,2-trifluoroethoxy)phenoxathiin-10,10-dioxide can be characterized by any of a number of its properties, including, but not limited to, melting point, differential scanning calorimetry, infrared spectroscopic spectrum or portions thereof, solubility, methods and conditions under which this form is prepared, and/or precipitated from solution, and, when in crystalline form, the crystalline form can be characterized according to the diffraction pattern or portions thereof