Image pickup systems capable of preventing blurred images are provided, in which a first sensor detects a variation in inclination of an image pickup device to generate a first sensing data, a second sensor detects a position movement from an image sensor in the image pickup device to generate a second sensing data and a driving unit is coupled to the image sensor. A processing module receives the first and second sensing data, integrates the first sensing data, calculates the integrated first sensing data and the second sensing data to obtain control information, and enables the driving unit to adjust the position of the image sensor according to the control information.