A multi-channel Media Access Control (MAC) method and apparatus for a Wireless Local Area Network (WLAN) device with a single radio interface are provided. The multi-channel MAC method includes sensing a common channel when a channel coordination window starts from a start point of a window repeating at regular periods, allocating at least two devices to a destination channel for the started channel coordination window using a channel utilization vector indicating use/nonuse for each of multiple channels, and transceiving a frame over the allocated destination channel.