Provided are methods of modifying the surface stress-activated reactivity of proppant particulates used in subterranean operations. In one embodiment, the methods comprise: providing a plurality of particulates, at least one of which comprises a mineral surface; providing a surface-treating reagent capable of modifying the stress-activated reactivity of a mineral surface of a particulate; and allowing the surface-treating reagent modify the stress-activated reactivity of at least a portion of the mineral surface of at least one particulate. In other embodiments, the methods comprise the use of particulates comprising a modified mineral surface in fluids introduced into subterranean formations.