发明申请
- 专利标题: Glycopegylated Follicle Stimulating Hormone
- 专利标题(中): 糖基化卵泡刺激激素
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申请号: US10581538申请日: 2004-12-03
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公开(公告)号: US20080015142A1公开(公告)日: 2008-01-17
- 发明人: Shawn DeFrees , Robert J. Bayer , Caryn Bowe
- 申请人: Shawn DeFrees , Robert J. Bayer , Caryn Bowe
- 国际申请: PCT/US04/40709 WO 20041203
- 主分类号: A61K38/24
- IPC分类号: A61K38/24 ; C07K14/59
摘要:
The present invention provides conjugates between follicle stimulating hormone and PEG moieties. The conjugates are linked via an intact glycosyl linking group that is interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from both glycosylated and unglycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto either an amino acid or glycosyl residue on the peptide. Also provided are pharmaceutical formulations including the conjugates. Methods for preparing the conjugates are also within the scope of the invention.
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