发明申请
- 专利标题： Acid Salt of Benzimidazole Derivative and Crystal Thereof
- 专利标题（中）： 苯并咪唑衍生物及其晶体的酸性盐
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申请号： US11667683申请日： 2005-11-14
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公开(公告)号： US20080015240A1公开(公告)日： 2008-01-17
- 发明人: Mitsuru Teramoto , Naoki Tsuchiya , Hiroshi Saitoh
- 申请人： Mitsuru Teramoto , Naoki Tsuchiya , Hiroshi Saitoh
- 优先权： JP2004-328843 20041112
- 国际申请： PCT/JP05/21196 WO 20051114
- 主分类号： A61K31/4184
- IPC分类号： A61K31/4184 ; A61P11/00 ; A61P15/00 ; A61P29/00 ; A61P3/00 ; C07D233/30
摘要：
The present invention provides acid salts, such as sulfate, hydrochloride, and methanesulfonate, of 4-(1-((4-methylbenzothiophen-3-yl)methyl)benzimidazol-2-ylthio)butanoic acid and the crystals thereof. These benzimidazole derivatives and the crystals thereof have an in vivo chymase inhibitory activity and can be used as a preventive or therapeutic agent for inflammatory diseases, allergic diseases, respiratory diseases, circulatory diseases, or bone/cartilage metabolic diseases.