A drawer slide assembly having an adjustment mechanism includes a slide, an adjusting lever, and a guide block. A first aperture, a pivoting part, and a second aperture are disposed on the slide. The adjusting lever includes a first end, a middle section pivoted to the slide, and a second end. The first end corresponds in position to the first aperture, and the second end corresponds in position to the second aperture. The guide block is pivoted to the second end of the adjusting lever. A protruding portion is disposed to the bottom of the guide block to slide in the second aperture by turning the guide block. The adjusting lever deflects and the first end slides in relation to the first aperture. A fastening member penetrates through the first end to connect to and fine tune for higher or lower of a drawer or similar object.