Aspects of a method and system for medium access control (MAC) layer specialization for voice and multimedia data streams are presented. Aspects of the method include determining a number of attempts for transmitting one or more medium access control (MAC) frames. Aspects of the system may include a processor that enables determination of a number of attempts for transmitting one or more MAC frames. A maximum number for such attempts may be determined based on one or more priority levels associated with different portions of multimedia information being communicated via a wireless medium and contained within the one or more MAC frames.