发明申请
- 专利标题: Antibody profiling for determination of patient responsiveness
- 专利标题(中): 用于确定患者反应性的抗体谱
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申请号: US11788232申请日: 2007-04-18
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公开(公告)号: US20080026485A1公开(公告)日: 2008-01-31
- 发明人: Wolfgang Hueber , William Robinson , Lawrence Steinman , Paul Utz , Mark Genovese
- 申请人: Wolfgang Hueber , William Robinson , Lawrence Steinman , Paul Utz , Mark Genovese
- 主分类号: G01N33/564
- IPC分类号: G01N33/564
摘要:
Compositions and methods are provided for prognostic classification of autoimmune disease patients into subtypes, which subtypes are informative of the patient's need for therapy and responsiveness to a therapy of interest. The patterns of circulating blood levels of serum autoantibodies and/or cytokines provides for a signature pattern that can identify patients likely to benefit from therapeutic intervention as well as discriminate patients that have a high probability of responsiveness to a therapy from those that have a low probability of responsiveness. Additionally, serum autoantibody and/or cytokine signature patterns can be utilized to monitor responses to therapy. Assessment of this signature pattern of autoantibodies and/or cytokines in a patient thus allows improved methods of care. In one embodiment of the invention, the autoimmune disease is rheumatoid arthritis.