发明申请
- 专利标题: Solid dosage form of enteric solid dispersion and method for producing the same
- 专利标题(中): 肠溶固体分散体的固体剂型及其制备方法
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申请号: US11888529申请日: 2007-08-01
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公开(公告)号: US20080038340A1公开(公告)日: 2008-02-14
- 发明人: Fumie Kusaki , Takafumi Hoshino , Naosuke Maruyama , Yuichi Nishiyama , Ikuo Fukui , Hiroshi Umezawa
- 申请人: Fumie Kusaki , Takafumi Hoshino , Naosuke Maruyama , Yuichi Nishiyama , Ikuo Fukui , Hiroshi Umezawa
- 专利权人: Shin-Etsu Chemical Co., Ltd.
- 当前专利权人: Shin-Etsu Chemical Co., Ltd.
- 优先权: JP2006-215401 20060808; JP2006-287860 20061023
- 主分类号: A61K9/10
- IPC分类号: A61K9/10 ; A61K47/30 ; A61K47/38
摘要:
Provided are a solid dosage form comprising an enteric solid dispersion that allows a drug in the preparation to be rapidly dissolved without compromising the solubility of the solid dispersion, and a method for producing the same. More specifically, provided is a solid dosage form comprising an enteric solid dispersion comprising a poorly soluble drug, an enteric polymer and a disintegrant, wherein the disintegrant is low-substituted hydroxypropylcellulose having an average particle size of 10 to 100 μm and a specific surface area measured by BET method of at least 1.0 m2/g. Moreover, provided is a method for producing a solid dosage form comprising an enteric solid dispersion, the method comprising steps of: spraying an enteric polymer solution in which a poorly soluble drug has been dispersed or dissolved, on a powder of low-substituted hydroxypropylcellulose having an average particle size of 10 to 100 μm and a specific surface area measured by BET method of at least 1.0 m2/g and serving as a disintegrant; and granulating the resultant; and drying.
公开/授权文献
- US08343548B2 Solid dosage form comprising solid dispersion 公开/授权日:2013-01-01
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