发明申请
- 专利标题: EphA2 BiTE molecules and uses thereof
- 专利标题(中): EphA2 BiTE分子及其用途
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申请号: US11645290申请日: 2006-12-21
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公开(公告)号: US20080044413A1公开(公告)日: 2008-02-21
- 发明人: Scott Hammond , Peter Kiener , Elizabeth Bruckheimer , Michael Kinch , Shannon Roff , Ralf Lutterbuese , Petra Lutterbuese , Bernd Schlereth , Patrick Baeuerle , Peter Kufer
- 申请人: Scott Hammond , Peter Kiener , Elizabeth Bruckheimer , Michael Kinch , Shannon Roff , Ralf Lutterbuese , Petra Lutterbuese , Bernd Schlereth , Patrick Baeuerle , Peter Kufer
- 主分类号: A61K39/395
- IPC分类号: A61K39/395 ; A61P31/00 ; A61P35/00 ; A61P43/00 ; C07K16/28
摘要:
The present invention relates to bispecific single chain antibodies comprising a first binding domain that immunospecifically binds to the T-cell antigen CD3 and a second binding domain that immunospecifically binds to the EphA2 receptor. Such bispecific single chain antibodies are encompassed by the term “EphA2-BiTEs.” The present invention further relates to methods and compositions designed for the treatment, prevention and/or management of disorders associated with aberrant expression and/or activity of EphA2. Such disorders include, but are not limited to, cancer, non-cancer hyperproliferative cell disorders, and infections. The invention further relates to vectors comprising polynucleotides encoding the EphA2-BiTEs of the invention, host cells transformed therewith, and their use in the production of said EphA2-BiTEs. The invention also provides compositions, including pharmaceutical compositions, comprising any of the aforementioned EphA2-BiTEs, polynucleotides or vectors either alone or in combination with one or more prophylactic or therapeutic agents. Also disclosed are methods of screening for said EphA2-BiTEs and kits comprising any of the aforementioned compositions and diagnostic reagents.