A fluid sampling system is disclosed comprising a fluid drawing device and a fluid sampling device. In one embodiment, the fluid drawing device comprises a venous arterial blood management protection apparatus having a housing with a fill chamber in fluid communication with a patient injection site, a piston positionable within the fill chamber to sealingly engage the fill chamber, wherein the piston has a first position and a second position, wherein movement of the piston from the first position to the second position generates a negative pressure in the fill chamber effective to draw fluid from the patient injection site into the fill chamber, biasing means for biasing the piston to the second position relative to the first position, and securing means for selectively securing the piston in the second position. In one embodiment, the fluid sampling device comprises a base portion having a canula, a handle, and a ridge extending around at least a portion of an outer surface; and a top portion having a flange adapted to engage said the ridge to couple the top portion to the base portion.