发明申请
- 专利标题: Combination Therapy
- 专利标题(中): 联合治疗
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申请号: US11667671申请日: 2005-11-15
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公开(公告)号: US20080058274A1公开(公告)日: 2008-03-06
- 发明人: Yechezkel Barenholz , Elena Khazanov
- 申请人: Yechezkel Barenholz , Elena Khazanov
- 国际申请: PCT/IL05/01200 WO 20051115
- 主分类号: A61K31/13
- IPC分类号: A61K31/13 ; A61K31/70 ; A61P43/00
摘要:
The present invention concerns a new medical treatment involving the combination of two active entities, as well as pharmaceutical compositions comprising the two active entities. Specifically, the invention provides a pharmaceutical composition comprising a stable lipid assembly comprising as a first active entity an apoptosis-affecting lipid which does not self-aggregate in a polar environment to form liposomes and a lipopolymer. The pharmaceutical composition further comprises, as the second active entity, a cytotoxic amphipathic weak base drug carried by the lipid assembly or by a different liposome. According to one embodiment, the apoptotic-affecting lipid is a pro-apoptotic lipid. A preferred pro-apoptotic lipid is ceramide, preferably C6-ceramide. The cytotoxic amphipathic weak base drug is preferably doxorubicin or a biologically active, anthracyline-based doxorubicin analog thereof.