发明申请
US20080063702A1 Liposomal Formulations Comprising an Amphipathic Weak Base Like Tempamine for Treatment of Neurodegenerative Conditions
审中-公开
包含两性弱碱的脂质体制剂，如Tempamine用于治疗神经退行性病症
- 专利标题： Liposomal Formulations Comprising an Amphipathic Weak Base Like Tempamine for Treatment of Neurodegenerative Conditions
- 专利标题（中）： 包含两性弱碱的脂质体制剂，如Tempamine用于治疗神经退行性病症
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申请号： US11662173申请日： 2005-09-11
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公开(公告)号： US20080063702A1公开(公告)日： 2008-03-13
- 发明人: Yechezkel Barenholz , Haim Ovadia , Pablo Kizelsztein
- 申请人： Yechezkel Barenholz , Haim Ovadia , Pablo Kizelsztein
- 国际申请： PCT/IL05/00961 WO 20050911
- 主分类号： A61K9/127
- IPC分类号： A61K9/127 ; A61K31/45 ; A61P25/00 ; A61P25/16
摘要：
The present invention provides the use of an amphipathic weak base having defined characteristics for the preparation of a pharmaceutical formulation for the treatment or prevention of neurodegenerative conditions. Preferably, the amphipathic weak base is encapsulated in a liposome. The invention also provides pharmaceutical formulations and methods of use thereof for the treatment or prevention of neurodegenerative conditions. A specific and preferred amphipathic weak base is tempamine (TMN). Further, preferably, tempamine is loaded in sterically stabilized liposomes (SSL-TMN).
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