The syringe includes a cylindrical barrel, a plunger in part disposed within the barrel and an elongated end cannula extending from the distal end of the barrel and formed integrally with the barrel of a single unitary plastic material. The plunger includes a distal end portion within the barrel having surfaces cooperable with surfaces along the interior of the barrel and enabling separation of the plunger end from remaining portions of the plunger in response to relative rotation of the plunger and barrel. A collar may be disposed about the cannula to seal with the lip of a medication vial. A clip is engageable within the plunger and barrel to fix the axial location of the plunger relative to the barrel at selected locations therealong.