A cannula is sized and configured to establish an access path through soft tissue to bone having a cancellous bone volume. A bone treatment tool is sized and configured to be introduced through the cannula into the cancellous bone volume. The bone treatment tool carries an operative structure that is capable of being enlarged in situ to contact a region of the cancellous bone volume. A nozzle is sized and configured to be introduced through the cannula into the cancellous bone volume. The nozzle includes a connector element that releasably couples to a dispenser of filling material to deliver filling material into the region of cancellous bone contacted by the operative structure.