A system and method for analyzing tissue healing may include an image capture device and a reference color marker of a predetermined color. A processing unit may be in communication with the image capture device, and be configured to receive image data from the image capture device. The image data may include image of a tissue site and the reference color marker. At least one image parameter may be adjusted based on at least a portion of the image of the reference color marker to normalize the image data. The normalized image data may be presented to a clinician.