An RF switch as described herein can communicate with different types of data transmitting devices such as RF readers, RFID tags, and other RF devices. The RF switch employs “plug-and-play” reader interface adapter modules, which can be pre-installed in the RF switch or downloaded to the RF switch as needed. Each interface adapter module represents or includes a different data protocol (or suite of protocols) that is compatible with a particular class, category, type, or group of data transmitting device. The use of these interface adapter modules enables the RF switch to be deployed in a protocol-agnostic form that is scalable and upgradeable in the field.