发明申请
- 专利标题: Passive Immunization and methods of treament for anthrax using antibodies
- 专利标题(中): 被动免疫和使用抗体治疗炭疽的方法
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申请号: US11041763申请日: 2005-01-24
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公开(公告)号: US20080081042A1公开(公告)日: 2008-04-03
- 发明人: Phillip R. Morrow , Angray S. Kang , Fei Wang , Ivy Jiang , Ritsuko Sawada , Wolfgang Scholz , Jeanne Morrow
- 申请人: Phillip R. Morrow , Angray S. Kang , Fei Wang , Ivy Jiang , Ritsuko Sawada , Wolfgang Scholz , Jeanne Morrow
- 优先权: USPCT/US05/01574 20050121
- 主分类号: A61K39/40
- IPC分类号: A61K39/40 ; C07K16/12
摘要:
A highly efficient method for generating human antibodies using recall technology is provided. In one aspect, human antibodies which are specific to the anthrax toxin are provided. In one aspect, human peripheral blood cells that have been pre-exposed to anthrax toxin are used in the SCID mouse model. This method results in high human antibody titers which are primarily of the IgG isotype and which contain antibodies of high specificity and affinity to desired antigens. The antibodies generated by this method can be used therapeutically and prophylactically for preventing or treating mammals exposed to anthrax. Thus, in one embodiment, a prophylactic or therapeutic agent used to counter the effects of anthrax toxin, released as a mechanism of bioterrorism, is provided. In one embodiment, a formulation and method for preventing and/or treating anthrax infection comprising a binding agent that prevents the assembly of the PA63 heptamer is also provided. Methods for diagnosis and methods to determine anthrax contamination are also described.
公开/授权文献
- US07438909B2 Immunization and treatment methods for anthrax 公开/授权日:2008-10-21