发明申请
US20080081811A1 Selective Inhibitors Against Cdk4 and Cdk6 Having Aminothiazole Skeleton
失效
对具有氨基噻唑骨架的Cdk4和Cdk6的选择性抑制剂
- 专利标题: Selective Inhibitors Against Cdk4 and Cdk6 Having Aminothiazole Skeleton
- 专利标题(中): 对具有氨基噻唑骨架的Cdk4和Cdk6的选择性抑制剂
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申请号: US11596735申请日: 2005-05-19
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公开(公告)号: US20080081811A1公开(公告)日: 2008-04-03
- 发明人: Yoshikazu Iwasawa , Jun Shibata , Tadashi Shimamura , Hideki Kurihara , Takashi Mita , Nobuhiko Kawanishi , Takashi Hashihayata , Mikako Kawamura , Takeshi Sagara , Sachie Arai , Hiroshi Hirai
- 申请人: Yoshikazu Iwasawa , Jun Shibata , Tadashi Shimamura , Hideki Kurihara , Takashi Mita , Nobuhiko Kawanishi , Takashi Hashihayata , Mikako Kawamura , Takeshi Sagara , Sachie Arai , Hiroshi Hirai
- 申请人地址: JP KUDANKITA CHIYODA-KU TOKYO JAPAN 10-28667
- 专利权人: BANYU PHARMACEUTICAL CO., LTD
- 当前专利权人: BANYU PHARMACEUTICAL CO., LTD
- 当前专利权人地址: JP KUDANKITA CHIYODA-KU TOKYO JAPAN 10-28667
- 优先权: JP2004-178974 20040521
- 国际申请: PCT/JP05/09593 WO 20050519
- 主分类号: A61K31/496
- IPC分类号: A61K31/496 ; A61K31/497 ; A61K31/505 ; A61K31/5377 ; A61P35/00 ; C07D239/32 ; C07D403/14 ; C07D413/14
摘要:
The present invention relates to a compound represented by Formula [I]: wherein X is O, S, NH or CH2; Y1, Y2, Y3, Y4 and Y5, which may be identical or different, are each CH or N; however, at least one of Y1, Y2, Y3, Y4 and Y5 is N; Z1 and Z2, which may be identical or different, are each CH or N; n is an integer from 1 to 3; R1 is a C3-C8 cycloalkyl group, a C6-C10 aryl group, an aliphatic heterocyclic ring or an aromatic heterocyclic ring, or a bicyclic aliphatic saturated hydrocarbon group; R2 and R3, which may be identical or different, are each a hydrogen atom, a lower alkyl group, a lower alkenyl group, a C3-C8 cycloalkyl group, a C6-C10 aryl group, an aromatic heterocyclic ring, or the like; and R4 is a hydrogen atom, a lower alkyl group, a C3-C6 cycloalkyl group or the like, or a pharmaceutically acceptable salt or ester thereof, and a selective inhibitor against Cdk4 and/or Cdk6 or an anticancer agent containing the compound or a pharmaceutically acceptable salt or ester thereof.
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