发明申请
US20080085929A1 INCLUSION COMPOUNDS OF FUMAGILLOL DERIVATIVE OR ITS SALT, AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME
有权
FUMAGILLOL衍生物或其盐的包含化合物和包含其的药物组合物
- 专利标题： INCLUSION COMPOUNDS OF FUMAGILLOL DERIVATIVE OR ITS SALT, AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME
- 专利标题（中）： FUMAGILLOL衍生物或其盐的包含化合物和包含其的药物组合物
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申请号： US11828025申请日： 2007-07-25
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公开(公告)号： US20080085929A1公开(公告)日： 2008-04-10
- 发明人: Jae Hyun KIM , Su Kyung LEE , Won Kyu CHOI , Jong Lae LIM , Soon Kil AHN , Hee Jong SHIN , Chung HONG
- 申请人： Jae Hyun KIM , Su Kyung LEE , Won Kyu CHOI , Jong Lae LIM , Soon Kil AHN , Hee Jong SHIN , Chung HONG
- 优先权： WO03/082845 20031009; KR2002/0016946 20020328
- 主分类号： A61K31/336
- IPC分类号： A61K31/336 ; A61P35/00 ; A61P35/04 ; C07D303/12 ; C07D303/36
摘要：
The present invention relates to an inclusion compound of fumagillol derivative or its salt with hydroxypropyl-β-cyclodextrin or sulfobutylether-7-β-cyclodextrin, and pharmaceutical compositions comprising the same. The inclusion compound according to the present invention has superior water solubility and stability while exhibiting low toxicity, rendering it valuable as an anticancer agent or inhibitor of tumor metastasis.