A system and method for predicting an inter-layer predicted slice of image data from at least two different reference layers, where the inter-layer predicted slice of image data itself resides on yet another layer, different from either of the two reference layers. At least one coded block from the inter-layer predicted slice of image data is encoded with an indication, indicating to a decoder that the at least one coded block is to be inter-layer multi-predicted from the at least two different reference layers. Identifications and corresponding prediction weights of the at least two different reference layers are also signaled to the decoder either in the coded block itself, or in the inter-layer predicted slice of image data.