A device for handling a fluid to be introduced into a fluidic device is described. The fluid handling device is designed for alignment with a fluidic device, such as a microfluidic device, where an exit port on the device aligns with one or more apertures in the fluidic for exchange of fluids there between. The fluid handling device includes one or more channels, with at least two pistons spaced apart contained in one or more of the channels. The gap between neighboring pistons define a space between the pistons for containing a fluid. Movement of the pistons from a first position to a second position is effective to move fluid from the fluid handling device into the fluidic device.