发明申请
US20080095853A1 Modified Release For Proton Pump Inhibitors 审中-公开
质子泵抑制剂的改性释放

Modified Release For Proton Pump Inhibitors
摘要:
An oral solid pharmaceutical dosage form comprising an acid sensitive proton pump inhibitor (PPI) as single active drug, releasing the PPI in two separate pulses, one immediate and one delayed. The PPI is formulated into a core material in the form of pellets, which are coated i.a. with a combination of a delayed release modifying layer and a lag time controlling layer. The pellets are further provided with an enteric coating layer. The application also relates to processes for preparing the dosage forms as well as their use in the treatment of gastrointestinal diseases.
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