发明申请
- 专利标题: Modified Release For Proton Pump Inhibitors
- 专利标题(中): 质子泵抑制剂的改性释放
-
申请号: US11718583申请日: 2005-11-02
-
公开(公告)号: US20080095853A1公开(公告)日: 2008-04-24
- 发明人: Niclas Clemmensen , Jan-Erik Lofroth , Katrin Walter , Peter Wang , Martin Wikberg
- 申请人: Niclas Clemmensen , Jan-Erik Lofroth , Katrin Walter , Peter Wang , Martin Wikberg
- 国际申请: PCT/SE05/01642 WO 20051102
- 主分类号: A61K9/16
- IPC分类号: A61K9/16 ; A61K31/4439 ; A61P1/00
摘要:
An oral solid pharmaceutical dosage form comprising an acid sensitive proton pump inhibitor (PPI) as single active drug, releasing the PPI in two separate pulses, one immediate and one delayed. The PPI is formulated into a core material in the form of pellets, which are coated i.a. with a combination of a delayed release modifying layer and a lag time controlling layer. The pellets are further provided with an enteric coating layer. The application also relates to processes for preparing the dosage forms as well as their use in the treatment of gastrointestinal diseases.