发明申请
US20080096897A1 5-(1,1'Biphenyl)-4-Yl-5-(4-(4-Aminoacylphenyl)-Piperazin)-1-Yl-Pyrimidine-2,4,6,-Trione Derivatives, As Inhibitors Of Zinc Metallondopeptidases, Their Preparation And Use
审中-公开
5-（1,1'-联苯基）-4-甲基-5-（4-（4-氨基酰基苯基）哌嗪）-1-基] - 嘧啶-2,4,6，-Trione衍生物，作为锌金属肽酶抑制剂， 他们的准备和使用
- 专利标题： 5-(1,1'Biphenyl)-4-Yl-5-(4-(4-Aminoacylphenyl)-Piperazin)-1-Yl-Pyrimidine-2,4,6,-Trione Derivatives, As Inhibitors Of Zinc Metallondopeptidases, Their Preparation And Use
- 专利标题（中）： 5-（1,1'-联苯基）-4-甲基-5-（4-（4-氨基酰基苯基）哌嗪）-1-基] - 嘧啶-2,4,6，-Trione衍生物，作为锌金属肽酶抑制剂， 他们的准备和使用
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申请号： US11661085申请日： 2005-08-16
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公开(公告)号： US20080096897A1公开(公告)日： 2008-04-24
- 发明人: Bernard Pirotte , Stephane Counerotte , Vanessa Detry , Francis Frankenne , Jean-Michel Foidart , Agnes Noel
- 申请人： Bernard Pirotte , Stephane Counerotte , Vanessa Detry , Francis Frankenne , Jean-Michel Foidart , Agnes Noel
- 优先权： EP04077400.2 20040824
- 国际申请： PCT/EP05/54035 WO 20050816
- 主分类号： A61K31/497
- IPC分类号： A61K31/497 ; A61K31/515 ; A61P29/00 ; A61P35/00 ; A61P37/00 ; C07D403/04 ; C07D403/14
摘要：
New Pyrimidinetrione derivatives represented by formula (I), wherein R1 and R2 are defined in the description, composition thereof, and methods of preparation are described. The compounds are useful in the treatment of disease involving metalloproteinases.
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