发明申请
US20080107691A1 VIBRIO CHOLERAE STRAINS VCUSM1 AND VCUSM4, METHOD OF PRODUCING SAME, AND VACCINE DERIVATIVES THEREOF
有权
VIBRIO CHOLERAE菌株VCUSM1和VCUSM4，其生产方法及其疫苗衍生物
- 专利标题： VIBRIO CHOLERAE STRAINS VCUSM1 AND VCUSM4, METHOD OF PRODUCING SAME, AND VACCINE DERIVATIVES THEREOF
- 专利标题（中）： VIBRIO CHOLERAE菌株VCUSM1和VCUSM4，其生产方法及其疫苗衍生物
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申请号： US11753311申请日： 2007-05-24
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公开(公告)号： US20080107691A1公开(公告)日： 2008-05-08
- 发明人: Manickam RAVICHANDRAN , Syed Atif ALI , Nur Haslindawaty Abdul Rashid , Lalitha PATTABIRAMAN , Zainul Fadziruddin ZAINUDDIN
- 申请人： Manickam RAVICHANDRAN , Syed Atif ALI , Nur Haslindawaty Abdul Rashid , Lalitha PATTABIRAMAN , Zainul Fadziruddin ZAINUDDIN
- 专利权人： UNIVERSITI SAINS MALAYSIA
- 当前专利权人： UNIVERSITI SAINS MALAYSIA
- 优先权： MY20033828 20031008
- 主分类号： A61K39/106
- IPC分类号： A61K39/106 ; C12N15/63 ; A61P31/04 ; C12N1/21
摘要：
Metabolic auxotroph of Vibrio cholerae 0139 synonym Bengal which has a mutation in its hem A gene and which is not capable of synthesizing aminolevulinic acid (ALA) de novo and which is obtained from a parent strain originally isolated from a patient's coproculture having all the identifying characteristics of Vibrio cholerae 0139 synonym Bengal is described. In this strain the hem A gene is mutated by inserting a kanamycin resistant gene cassette. Another metabolic auxotroph of Vibrio cholerae 01 El Tor where the hem A gene is mutated by a frame shift mutation is disclosed. Methods of producing the strains are disclosed.
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