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发明申请
US20080108824A1 Medical Devices Incorporating a Bioactive and Methods of Preparing Such Devices 审中-公开
纳入生物活性的医疗器械及其制备方法

Medical Devices Incorporating a Bioactive and Methods of Preparing Such Devices
摘要：
One embodiment provides a medical device comprising a base material and a bioactive in contact with the base material, the bioactive having a proton binding site with a non-ionic form and an ionic form, the bioactive being less soluble in water when the proton binding site is in the non-ionic form than when the proton binding site is in the ionic form, wherein at least 5% w/w of the bioactive is present with the proton binding site in the non-ionic form and wherein the bioactive is not an anesthetic. Another embodiment provides such a medical device where the bioactive is an anesthetic and where the device is not a ureteral stent. Another aspect provides method of manufacturing such devices.
摘要（中）：

一个实施方案提供了包含基础材料和与基底材料接触的生物活性的医疗装置，所述生物活性物质具有非离子形式和离子形式的质子结合位点，当质子结合位点 与质子结合位点处于离子形式相比是非离子形式，其中至少5％w / w的生物活性存在于非离子形式的质子结合位点，并且其中生物活性物质不是 麻药。 另一个实施方案提供了这样的医疗装置，其中生物活性是麻醉剂，并且其中装置不是输尿管支架。 另一方面提供了制造这种装置的方法。

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