发明申请
US20080108830A1 Production method of optically active 2-[(N-benzylprolyl)amino]benzo-phenone compound
审中-公开
光学活性2 - [(N-苄基脯氨酰基)氨基]苯并苯酮化合物的制备方法
- 专利标题: Production method of optically active 2-[(N-benzylprolyl)amino]benzo-phenone compound
- 专利标题(中): 光学活性2 - [(N-苄基脯氨酰基)氨基]苯并苯酮化合物的制备方法
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申请号: US11979108申请日: 2007-10-31
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公开(公告)号: US20080108830A1公开(公告)日: 2008-05-08
- 发明人: Takayuki Hamada , Kunisuke Izawa , Vadim Soloshonok
- 申请人: Takayuki Hamada , Kunisuke Izawa , Vadim Soloshonok
- 申请人地址: JP Tokyo
- 专利权人: AJINOMOTO CO. INC
- 当前专利权人: AJINOMOTO CO. INC
- 当前专利权人地址: JP Tokyo
- 主分类号: C07D207/16
- IPC分类号: C07D207/16 ; C07F15/04
摘要:
The present invention relates to a production method of optically active 2-[(N-benzylprolyl)amino]-5-chlorobenzophenone (3) or a salt thereof, which includes reacting optically active N-benzylproline (1) with 2-amino-5-chlorobenzophenone (2) in acetonitrile and in the presence of an amide compound and thionyl chloride. According to the method of the present invention, optically active 2-[(N-benzylprolyl)amino]-5-chlorobenzophenone (3) or a salt thereof can be conveniently produced at a high purity and in a high yield: wherein * shows an asymmetric carbon atom and the configuration of the asymmetric carbon atom is S or R.