A vascular access catheter that has a substantially distal end portion that has a distal tip. The distal end portion has a sloped face in the distal portion of the catheter, an outflow lumen aperture, and a second inflow lumen aperture. The outflow lumen aperture is substantially completely open in the sloped face and exits the distal portion adjacent the distal tip. The catheter has a guidewire lumen that is located at least in the region of the distal portion of the catheter and is capable of receiving a guidewire. The guidewire lumen has a proximal aperture and a distal aperture that extends distally of the outflow lumen aperture. The guidewire distal aperture exits at the distal most edge of the distal end portion. The guidewire lumen may extend a partial length of the catheter or substantially the entire length of the catheter. The catheter distal portion may be substantially straight or curved.