Embodiments of the present invention address deficiencies of the art in respect to message response management and provide a method, system and computer program product for motivating and de-motivating message responses. In one embodiment of the invention, a message reply motivation and de-motivation method can be provided. The method can include composing a message, addressing the message to at least one addressee, associating a reply preference specifying whether or not a recipient is to reply to the message, and forwarding the reply preference to the addressee. Upon receipt, the message can be displayed in a message viewer, and any reply preference for the message can be analyzed to determine if the reply preference specifies whether or not to reply to the message. Thereafter, the reply preference can be applied in the message viewer.