An antimicrobial composition is formed from about 5 to about 25 wt % of an antimicrobial formulation and about 75 to about 95 wt % of a polyurethane resin or polyurethane hybrids, copolymers, or mixtures with other polymers such as polyesters, nitrites, PVC, and synthetic rubber latexes. The antimicrobial formulation is formed from about 60 to about 90 wt % of an antimicrobial material, about 1 to about 30 wt % calcium chelator, about 0.001 to about 2 wt % color and appearance enhancing pigments, about 0.001 to about 2 wt % of surfactants, and about 0.5 to about 10 wt % lubricant. The polyurethane resin may be a nonaqueous or aqueous latex dispersion or a prepolymer that polymerizes when exposed to moisture. An antimicrobial coating may be formed on the surface of an article by applying an antimicrobial composition to the article; if a polyurethane prepolymer is used, the composition is exposed to moisture and if an aqueous or nonaqueous dispersion is used, the water or solvent is evaporated. A coating may also be formed by making a mixture of the antimicrobial formulation and a resin and molding, overmolding, or extruding the article from the compounded mixture.