发明申请
US20080132494A1 Thiazole and oxazole-substituted arylamides as P2X3 and P2X2/3 antagonists
有权
噻唑和恶唑取代的芳基酰胺作为P2X3和P2X2 / 3拮抗剂
- 专利标题： Thiazole and oxazole-substituted arylamides as P2X3 and P2X2/3 antagonists
- 专利标题（中）： 噻唑和恶唑取代的芳基酰胺作为P2X3和P2X2 / 3拮抗剂
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申请号： US11983225申请日： 2007-11-08
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公开(公告)号： US20080132494A1公开(公告)日： 2008-06-05
- 发明人: Michael Patrick Dillon , Ronald Charles Hawley , Li Chen , Lichun Feng , Minmin Yang
- 申请人： Michael Patrick Dillon , Ronald Charles Hawley , Li Chen , Lichun Feng , Minmin Yang
- 专利权人： Roche Palo Alto LLC,Roche R&D Center China, Ltd.
- 当前专利权人： Roche Palo Alto LLC,Roche R&D Center China, Ltd.
- 主分类号： A61K31/541
- IPC分类号： A61K31/541 ; A61P13/02 ; A61P25/00 ; A61P11/00 ; C07D417/02 ; C07D277/30 ; C07D263/32 ; A61K31/4439 ; A61K31/501 ; A61K31/496 ; A61K31/426 ; A61K31/421 ; A61K31/5377 ; A61K31/497
摘要：
Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, R1 is a group of formula A or formula B, and X, R2, R3, R4, R5, R6, Ra and Rb are as defined herein. Also provided are methods of using the compounds for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist and methods of making the subject compounds.
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