发明申请
US20080138849A1 USE OF MDCK CELL LINE TO PREDICT CORNEAL PENETRATION OF DRUGS
审中-公开
使用MDCK细胞系预测药物的角膜渗透
- 专利标题： USE OF MDCK CELL LINE TO PREDICT CORNEAL PENETRATION OF DRUGS
- 专利标题（中）： 使用MDCK细胞系预测药物的角膜渗透
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申请号： US11871426申请日： 2007-10-12
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公开(公告)号： US20080138849A1公开(公告)日： 2008-06-12
- 发明人: Andrew RUSINKO , Mark R. HELLBERG , Jesse Albert May , Geoffrey Robert Owen
- 申请人： Andrew RUSINKO , Mark R. HELLBERG , Jesse Albert May , Geoffrey Robert Owen
- 申请人地址： CH Hunenberg
- 专利权人： ALCON, INC.
- 当前专利权人： ALCON, INC.
- 当前专利权人地址： CH Hunenberg
- 主分类号： C12Q1/02
- IPC分类号： C12Q1/02 ; A61K47/00 ; A61P27/02
摘要：
A new method of evaluating the ability of drug molecules to penetrate the cornea is described. The permeation rate of the drug molecules in MDCK cells is utilized to predict the ability of the molecules to penetrate the cornea. The method is useful for in vitro screening of potential new ophthalmic drugs, as well as in the design of new drug molecules for topical ocular administration.