- 专利标题： Derivatives of partially desulphated glycosaminoglycans as heparanase inhibitors, endowed with antiangiogenic activity and devoid of anticoagulating effect
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申请号： US11980741申请日： 2007-10-31
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公开(公告)号： US20080139503A1公开(公告)日： 2008-06-12
- 发明人: Benito Casu , Giangiacomo Torri , Anna Maria Naggi , Giuseppe Giannini , Claudio Pisano , Sergio Penco
- 申请人： Benito Casu , Giangiacomo Torri , Anna Maria Naggi , Giuseppe Giannini , Claudio Pisano , Sergio Penco
- 申请人地址： IT Roma
- 专利权人： SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.p.A.
- 当前专利权人： SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.p.A.
- 当前专利权人地址： IT Roma
- 优先权： ITRM2000A000041 20000125; ITPCT/IT01/00034 20010124; ITPCT/IT01/00472 20010912
- 主分类号： A61K31/726
- IPC分类号： A61K31/726 ; A61K31/727 ; C08B37/10 ; C08B37/00 ; C12P19/26 ; A61K47/26 ; A61P1/00 ; A61P9/00 ; A61P37/00
摘要：
Partially desulphated glycosaminoglycan derivatives are described, particularly heparin, and more particularly a compound of formula (I) where the U, R and R1 groups have the meanings indicated in the description. These glycosaminoglycan derivatives have antiangiogenic and heparanase-inhibiting activity and are devoid of anticoagulant activity.
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