发明申请
US20080145413A1 Lipids and lipid assemblies comprising transfection enhancer elements
审中-公开
包含转染增强子元件的脂质和脂质组件
- 专利标题： Lipids and lipid assemblies comprising transfection enhancer elements
- 专利标题（中）： 包含转染增强子元件的脂质和脂质组件
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申请号： US11642347申请日： 2006-12-19
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公开(公告)号： US20080145413A1公开(公告)日： 2008-06-19
- 发明人: Steffen Panzner , Christian Reinsch , Evgenios Siepi
- 申请人： Steffen Panzner , Christian Reinsch , Evgenios Siepi
- 主分类号： A61K9/127
- IPC分类号： A61K9/127 ; A61K31/7052 ; A61P29/00 ; A61P35/00 ; A61P37/00 ; C07C229/00 ; C12N15/88
摘要：
This disclosure describes structural elements that enhance fusogenicity of lipids and lipid assemblies (e.g. liposomes) with biological membranes, in particular cell membranes, and use of such structures. The elements are pH sensitive in terms of charge and hydrophilicity and undergo a polar—apolar transition when exposed to low pH.
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